| Autor: |
B B, Dean, D, Aguilar, L F, Johnson, J E, McGuigan, W C, Orr, R, Fass, N, Yan, D, Morgenstern, R W, Dubois |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Alimentary pharmacologytherapeutics. 27(4) |
| ISSN: |
1365-2036 |
| Popis: |
Respondents with gastro-oesophageal reflux disease (GERD) report having a variety of atypical manifestations. The relationship between these manifestations and disease severity, night-time GERD and functioning has not been determined.To determine if atypical manifestations are related to increased disease severity, night-time GERD and decreased functioning.A web survey among US adults was conducted, using a validated GERD screener. Frequency of night-time and daytime typical symptoms (acid regurgitation and heartburn) and atypical manifestations were assessed. Respondents were classified as night-time GERD or daytime GERD based on typical symptom frequency. Prevalence of frequent atypical manifestations (or =2 days or nights/week) was assessed.Gastro-oesophageal reflux disease cases had a higher prevalence of each atypical manifestation (P0.05 for all) compared with controls. Night-time GERD respondents had a higher prevalence of atypical manifestations compared with daytime GERD respondents (P0.05 for most manifestations) and the prevalence of atypical manifestations increased with GERD symptom severity (P0.05 for most). Those with atypical manifestations reported lower functioning scores (P0.05 for most).Respondents with typical GERD symptoms commonly report atypical manifestations, especially those with night-time symptoms and those with greater underlying GERD severity. Respondents with GERD and atypical manifestations had more impaired functioning than those with typical symptoms only. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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