| Autor: |
N P, Salazar, M C, Saniel, M H, Estoque, F A, Talao, D G, Bustos, L P, Palogan, A I, Gabriel |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
The Southeast Asian journal of tropical medicine and public health. 21(3) |
| ISSN: |
0125-1562 |
| Popis: |
Clinical trials on oral clindamycin as an antimalarial in hospitalized patients and residents of endemic communities were conducted in the Philippines between May 1984 and December 1985. Seven and 9 qualified subjects in hospital were treated with 300 mg (regimen A) and 600 mg (regimen B) respectively, twice daily for 5 days. Eighteen patients seen at a rural health unit were given the lower dosage. On the basis of the 28-day extended in vivo test of WHO, P. falciparum in all but one patient showed susceptibility to the drug as a blood schizontocide hence, the clinical cure of malaria. Side effects were few and self-limiting. Ten other patients on regimen A were cured within the 7- and/or 28-day extended test period. Clindamycin per se is currently one of the few alternatives in the treatment of clinically moderate drug-resistant malaria. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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