| Autor: |
A, Danysz, K, Oledzka, M, Bukowska-Kiliszek |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Polish journal of pharmacology. 46(5) |
| ISSN: |
1230-6002 |
| Popis: |
Administration of coenzyme Q-10 (10 mg/kg) once a day for 4 weeks decreased the arterial blood pressure in SHR's. Enalapril and nitrendipine administered in a single dose caused significant decrease of blood pressure. Application of enalapril and nitrendipine to rats chronically pretreated with coenzyme Q-10 revealed, that the maximal hypotensive effect was not greater, but it lasted much (ca. 2-times) longer. Independently of mechanism of this interaction it may be suggested that the chronic administration of coenzyme Q-10 would create the possibility of significant decrease of the frequency of some antihypertensive drug administration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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