Autor:	Takahiro, Kawamata, Masanori, Nagatomo, Masayuki, Inoue
Rok vydání:	2017
Předmět:	Cyclization Acylation Molecular Conformation Bridged Bicyclo Compounds Heterocyclic Photochemical Processes
Zdroj:	Journal of the American Chemical Society. 139(5)
ISSN:	1520-5126
Popis:	Zaragozic acid C (1) was isolated as a potent squalene synthase inhibitor. The 2,8-dioxabicyclo[3.2.1]octane core of 1 is decorated with the three hydroxycarbonyl (C3,4,5), two hydroxy (C4,7), one acyloxy (C6), and one alkyl (C1) groups. Installation of the contiguous C4- and C5-fully substituted carbons presents a formidable synthetic challenge. Our approach to address this problem used a two-step photochemical C(sp
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e29511bfe50abea2a86c6d252f87e72e https://pubmed.ncbi.nlm.nih.gov/28092952 Zobrazit plný text záznamu