| Autor: |
Annabel C, Murphy, Hui, Hong, Steve, Vance, R William, Broadhurst, Peter F, Leadlay |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Chemical communications (Cambridge, England). 52(54) |
| ISSN: |
1364-548X |
| Popis: |
An in vitro model system based on a ketosynthase domain of the erythromycin polyketide synthase was used to probe the apparent substrate tolerance of ketosynthase domains of the mycolactone polyketide synthase. A specific residue change was identified that led to an emphatic increase in turnover of a range of substrates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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