| Autor: |
Y C, Yang, V J, Hruby, C B, Heward, M E, Hadley |
| Rok vydání: |
1980 |
| Předmět: |
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| Zdroj: |
International journal of peptide and protein research. 15(2) |
| ISSN: |
0367-8377 |
| Popis: |
The solid phase synthesis of alpha-melanocyte stimulating hormone (alpha-MSH) using the benzhydrylamine resin and a number of recently described side chain protecting groups is given. The carboxamide terminal peptide was obtained directly by treatment of the peptide resin with liquid hydrogen fluoride at 0 degrees in the presence of carbonium ion scavengers. The solid phase synthesis of the C-terminal carboxylate hormone, porcine beta-melanocyte stimulating hormone (beta p-MSH), using a 1% cross-linked Merrifield resin and the same side chain protecting groups as in the alpha-MSH synthesis also is presented. Purification of both peptides was carried out by conventional chromatographic techniques. Both hormones were fully active and beta p-MSH was slightly more potent than previously reported in the literature. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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