Risk Factors Associated with Mortality and Increased Drug Costs in Nonvariceal Upper Gastrointestinal Bleeding
| Autor: | Mingliang, Lu, Gang, Sun, Xiu-li, Zhang, Xiao-mei, Zhang, Qing-sen, Liu, Qi-yang, Huang, James W Y, Lau, Yun-sheng, Yang |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Epinephrine Stomach Diseases Blood Pressure Comorbidity Esophageal Diseases Drug Costs Hemostatics Cohort Studies Recurrence Risk Factors Humans Vasoconstrictor Agents Blood Transfusion Endoscopy Digestive System Stomach Ulcer Duodenal Diseases Aged Retrospective Studies Mallory-Weiss Syndrome Argon Plasma Coagulation Anti-Inflammatory Agents Non-Steroidal Age Factors Thrombin Length of Stay Middle Aged Cross-Sectional Studies Peptic Ulcer Hemorrhage Duodenal Ulcer Multivariate Analysis Linear Models Female Gastrointestinal Hemorrhage |
| Zdroj: | Hepato-gastroenterology. 62(140) |
| ISSN: | 0172-6390 |
| Popis: | To determine risk factors associated with mortality and increased drug costs in patients with nonvariceal upper gastrointestinal bleeding.We retrospectively analyzed data from patients hospitalized with nonvariceal upper gastrointestinal bleeding between January 2001-December 2011. Demographic and clinical characteristics and drug costs were documented. Univariate analysis determined possible risk factors for mortality. Statistically significant variables were analyzed using a logistic regression model. Multiple linear regression analyzed factors influencing drug costs. p0.05 was considered statistically significant.The study included data from 627 patients. Risk factors associated with increased mortality were age60, systolic blood pressure100 mmHg, lack of endoscopic examination, comorbidities, blood transfusion, and rebleeding. Drug costs were higher in patients with rebleeding, blood transfusion, and prolonged hospital stay.In this patient cohort, re-bleeding rate is 11.20% and mortality is 5.74%. The mortality risk in patients with comorbidities was higher than in patients without comorbidities, and was higher in patients requiring blood transfusion than in patients not requiring transfusion. Rebleeding was associ-ated with mortality. Rebleeding, blood transfusion, and prolonged hospital stay were associated with increased drug costs, whereas bleeding from lesions in the esophagus and duodenum was associated with lower drug costs. |
| Databáze: | OpenAIRE |
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