[In-transit metastasis in melanoma: Efficacy of topical imiquimod combined with carbon dioxide laser or with electrocautery]
| Autor: | F-Z, Elfatoiki, C, Longvert, T, Clerici, I, Bourgault-Villada, C, Roudier-Pujol, E, Vasseur, P, Saiag |
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| Jazyk: | francouzština |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Leg Imiquimod Skin Neoplasms Sentinel Lymph Node Biopsy Palliative Care Remission Induction Interferon-alpha Antineoplastic Agents Administration Cutaneous Combined Modality Therapy Fatal Outcome Lymphatic Metastasis Aminoquinolines Disease Progression Electrocoagulation Lasers Gas Humans Laser Therapy Facial Neoplasms Melanoma Aged |
| Zdroj: | Annales de dermatologie et de venereologie. 141(2) |
| ISSN: | 0151-9638 |
| Popis: | In-transit metastases in cutaneous melanoma are common and difficult to manage. Therapy is mainly palliative. Use of topical imiquimod has been assessed for surface metastases.We report on four patients with cutaneous melanoma metastases treated with topical imiquimod associated with carbon dioxide laser in the first two patients and with electrocoagulation in the two others. For two patients, we noted complete regression of the lesions after 15 and 18 months. For the two others, treatment was stopped after 9 to 10 months because of progression of subcutaneous metastasis and distant metastasis.Topical imiquimod is an alternative treatment used in superficial in-transit metastasis of melanoma. Its use as a monotherapy is sometimes ineffective. We elected to use combined pre-treatment with carbon dioxide laser or electrocoagulation in order to potentiate the action of imiquimod. This simple and inexpensive therapeutic strategy constitutes a palliative treatment that can allow prolonged local control of cutaneous metastasis. |
| Databáze: | OpenAIRE |
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