| Autor: |
S H, Pang, Z R, Guo, X T, Liang |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Yao xue xue bao = Acta pharmaceutica Sinica. 32(7) |
| ISSN: |
0513-4870 |
| Popis: |
Four classes of 25 tyrosine protein kinase (TPK) inhibitors were designed and synthesized. Compounds 1-10 were tested to inhibit TPK of HL-60 leukemia cell using 32P-ATP method, and some of them exhibit evident inhibitory activities. Their structure-activity relationship is similar to that of TPK inhibitors reported in literatures. Compounds 11-25 were tested to inhibit TPK of normal rat spleen cell using ELISA method and their SAR is different from that using 32P-ATP method. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
