| Autor: |
B, Gold, K M, Church, R L, Wurdeman, Y, Zhang, F X, Chen |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
IARC scientific publications. (105) |
| ISSN: |
0300-5038 |
| Popis: |
The syntheses of N-2-chloroethyl-N-nitrosoureas (Cl-ENU) that are covalently linked to a series of minor groove binding lexitropsins related to distamycin A are reported. The lexitropsins of 2-Cl-ENU show a sequence specificity for alkylating an adenine toward the ends of its DNA affinity binding domains. The reaction of DNA with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea does not yield these products. Therefore, the linking of the 2-Cl-ENU to the minor groove binder qualitatively and quantitatively alters the DNA observed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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