Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H
| Autor: | Haibo, He, Xiaomei, Li, Haili, Yu, Shu, Zhu, Yumin, He, Katsuko, Komatsu, Dongyan, Guo, Xiaoqin, Li, Junzhi, Wang, Huajun, Luo, Daoxiang, Xu, Kun, Zou |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Drug Evaluation Preclinical Poly (ADP-Ribose) Polymerase-1 H(+)-K(+)-Exchanging ATPase Mice Random Allocation Animals Stomach Ulcer Oleanolic Acid Gastric Juice Aspirin Ethanol Caspase 3 Plant Extracts Cytochromes c Aralia Saponins Anti-Ulcer Agents Caspase 9 Mitochondria Molecular Docking Simulation Apoptotic Protease-Activating Factor 1 Proto-Oncogene Proteins c-bcl-2 Gastric Mucosa Regional Blood Flow Phytotherapy |
| Zdroj: | Journal of natural medicines. 73(2) |
| ISSN: | 1861-0293 |
| Popis: | The aim of this study was to elucidate the gastroprotective activity and possible mechanism of involvement of araloside A (ARA) against ethanol- and aspirin-induced gastric ulcer in mice. The experimental mice were randomly divided into control, model, omeprazole (20 mg/kg, orally) and ARA (10, 20 and 40 mg/kg, orally). Gastric ulcer in mice was induced by intragastric administration of 80% ethanol (10 mL/kg) containing 15 mg/mL aspirin 4 h after drug administration on day 7. The results indicated that ARA could significantly raise gastric juice volume and acidity; ameliorate gastric mucosal blood flow, gastric binding mucus volume, ulcer index and ulcer inhibition rate; suppress H |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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