Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family
| Autor: | P C, Maisonpierre, M, Goldfarb, G D, Yancopoulos, G, Gao |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Aging
Base Sequence Sequence Homology Amino Acid Molecular Sequence Data Restriction Mapping Brain Heart Receptors Cell Surface DNA Receptor TIE-1 Protein-Tyrosine Kinases Embryo Mammalian Receptor TIE-2 Rats Receptors TIE Oligodeoxyribonucleotides Organ Specificity Multigene Family Animals Humans RNA Amino Acid Sequence Cloning Molecular In Situ Hybridization |
| Zdroj: | Oncogene. 8(6) |
| ISSN: | 0950-9232 |
| Popis: | We have isolated rat cDNAs that encode two related receptor-like tyrosine kinases. One of these receptors, TIE-1, is the rat homolog of a recently described human receptor-like kinase termed TIE (Partanen et al., 1992). The related TIE-2 receptor has the same organization of amino acid sequence motifs characteristic of TIE-1: two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin III-like repeats in the extracellular region and a short kinase insert sequence and C-terminal tail in the intracellular region. The amino acid sequences of the intracellular and extracellular regions of TIE-1 and TIE-2 are 79% and 32% identical respectively. Both tie genes are broadly expressed in embryonic, neonatal and adult tissues, accounted for largely by their coexpression in endothelial cells. The tie-2 gene is also uniquely expressed in several additional embryonic tissues, including the lens epithelium and the heart epicardium. |
| Databáze: | OpenAIRE |
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