Expression of Toll-like receptors in the human decidua
| Autor: | G, Krikun, C J, Lockwood, V M, Abrahams, G, Mor, M, Paidas, S, Guller |
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| Rok vydání: | 2007 |
| Předmět: |
Lipopolysaccharides
Reverse Transcriptase Polymerase Chain Reaction Interleukins Pregnancy Trimester Third Toll-Like Receptors NF-kappa B Endothelial Cells Peptidoglycan Immunohistochemistry Immunity Innate Adaptor Proteins Vesicular Transport Endometrium Pregnancy Trimester First Poly I-C Pregnancy Myeloid Differentiation Factor 88 Decidua Humans Female RNA Messenger Cells Cultured Signal Transduction |
| Zdroj: | Histology and histopathology. 22(8) |
| ISSN: | 1699-5848 |
| Popis: | Successful trophoblast invasion and transformation of the maternal spiral arteries requires that the pregnant endometrium (i.e., decidua) act in an immunologically paradoxical fashion, accepting the semi-allogenic placenta, while maintaining host defenses against an array of microbial pathogens. In contrast to the growing evidence that the immune surveillance molecules known as Toll-like receptors (TLRs) are expressed by trophoblasts and fetal membranes, to date, no studies have been conducted on the decidua.Decidual tissues and cells were obtained from women undergoing first trimester elective terminations or repeat Cesarean sections and analyzed at both the protein and mRNA level.We now demonstrate for the first time that human decidua differentially express TLRs and their downstream signaling molecules as well as TLR stimulated induction of cytokine production in the first and third trimester of pregnancy.These findings suggest that the decidua is a critical component of the innate immune response in pregnancy. Moreover, the results have implications for the success or failure of compromised pregnancies in early or late gestation. |
| Databáze: | OpenAIRE |
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