In vivo efficacy of antifungal oxoaporphine alkaloids in experimental disseminated candidiasis

Autor:	A M, Clark, E S, Watson, M K, Ashfaq, C D, Hufford
Rok vydání:	1987
Předmět:	Mice Mice Inbred ICR Antifungal Agents Aporphines Candidiasis Animals Female Microbial Sensitivity Tests Kidney
Zdroj:	Pharmaceutical research. 4(6)
ISSN:	0724-8741
Popis:	The efficacy of three antifungal oxoaporphine alkaloids, liriodenine, liriodenine methiodide, and oxoglaucine methiodide, was determined in a mouse model of disseminated candidiasis. Mice infected with a lethal dose of Candida albicans NIH B311 were administered varying doses of each drug intraperitoneally or intravenously 7 hr postinfection. Reductions in the number of colony-forming units (CFU) recovered per milligram of kidney tissue were observed in drug-treated animals compared to vehicle-treated control mice. Significance was determined by the Wilcoxon nonparametric rank sum test. Intravenous administration of both liriodenine and liriodenine methiodide resulted in a significant reduction in the number of recovered CFU, while there was no significant response to treatment with oxoglaucine methiodide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e1673c09ea6af90e010d563deacfb3a7 https://pubmed.ncbi.nlm.nih.gov/3508563 Zobrazit plný text záznamu Full text from SpringerLink