A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch

Autor:	Liping, Chen, Bixia, Weng, Huimin, Li, Haonan, Wang, Qian, Li, Xiaoyan, Wei, Hui, Deng, Sicen, Wang, Chengxi, Jiang, Renyu, Lin, Jianzhang, Wu
Rok vydání:	2018
Předmět:	Mice Inbred BALB C Lung Neoplasms NF-kappa B Antineoplastic Agents Apoptosis Xenograft Model Antitumor Assays Mice RAW 264.7 Cells A549 Cells Cell Line Tumor Toxicity Tests Pyroptosis Animals Humans Female Sulfhydryl Compounds Pyrans Signal Transduction
Zdroj:	Apoptosis : an international journal on programmed cell death. 24(1-2)
ISSN:	1573-675X
Popis:	Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-κB signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e12fd48a4172de5fcbb9af3b45e3ebb6 https://pubmed.ncbi.nlm.nih.gov/30519834 Zobrazit plný text záznamu Full text from SpringerLink