| Autor: |
M S, South, T A, Dice, J J, Parlow |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Biotechnology and bioengineering. 71(1) |
| ISSN: |
0006-3592 |
| Popis: |
A parallel solution-phase library synthesis of alpha-ketoamides is described. The two-step library synthesis is accomplished using polymer-assisted solution-phase (PASP) synthesis techniques. This high-yielding, multi-step sequence utilizes sequestering resins for the removal of reactants, reactant by-products, and tagged reagents. The first step of the library synthesis utilizes PASP resins to mediate the amide coupling of an alpha-hydroxy acid with an amine. The second step uses PASP resins for the periodinane oxidation of the alpha-hydroxy acid to an alpha-ketoamide leaving highly pure products after simple filtration and evaporation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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