Potent nonpeptide endothelin antagonists: synthesis and structure-activity relationships of pyrazole-5-carboxylic acids

Autor:	J, Zhang, S, Didierlaurent, M, Fortin, D, Lefrançois, E, Uridat, J P, Vevert
Rok vydání:	2000
Předmět:	Structure-Activity Relationship Endothelins Carboxylic Acids Pyrazoles
Zdroj:	Bioorganicmedicinal chemistry letters. 10(22)
ISSN:	0960-894X
Popis:	We have previously reported the identification of pyrazole-5-carboxylic acids as a new class of endothelin antagonists from low affinity pyrazol-5-ol ligands, which were obtained by random screening assays. We describe herein the synthesis and the structure activity relationships (SARs) of these pyrazole-5-carboxylic acids with potent ET(A) selective, mixed ET(A)/ET(B) or moderately ET(B) selective antagonist activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e12b6df9fc209bb97dfea8b9fa8a36c4 https://pubmed.ncbi.nlm.nih.gov/11086733 Zobrazit plný text záznamu Full Text from ScienceDirect