Antihypertensive profile of the angiotensin-converting enzyme inhibitors CI-906 and CI-907
| Autor: | M J, Ryan, D M, Boucher, D M, Cohen, B J, Olszewski, R M, Singer, R D, Smith, H R, Kaplan |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Captopril Hypertension Renal Indoles Dose-Response Relationship Drug Quinapril Angiotensin-Converting Enzyme Inhibitors Rats Inbred Strains Dipeptides Isoquinolines Rats Renin-Angiotensin System Disease Models Animal Kinetics Dogs Hypertension Renovascular Enalapril Tetrahydroisoquinolines Hypertension Animals Female Antihypertensive Agents |
| Zdroj: | Federation proceedings. 43(5) |
| ISSN: | 0014-9446 |
| Popis: | CI-906 and CI-907, new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors, were examined for antihypertensive effects in unanesthetized hypertensive rats and dogs. In two-kidney, one-clip Goldblatt hypertensive rats, single oral daily doses (0.03-30 mg/kg) produced dose-dependent decreases in blood pressure; a single 3 mg/kg oral dose lowered blood pressure to normotensive levels. In spontaneously hypertensive rats, 30 mg/(kg X day) orally administered for 5 consecutive days achieved the same blood pressure decrease as that obtained on the first day in the renal hypertensive rats. In diuretic-pretreated renal hypertensive dogs, a 10 mg/kg oral dose decreased blood pressure by 25%. No adverse side effects were observed with CI-906 and CI-907 in any of the conscious animals. These studies indicate that CI-906 and CI-907 are potent, orally active antihypertensive agents without any apparent limiting side effects. |
| Databáze: | OpenAIRE |
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