Association between Polymorphisms in the Pf
| Autor: | Mathieu, Gendrot, Silman, Diawara, Marylin, Madamet, Mame Bou, Kounta, Sébastien, Briolant, Khalifa Ababacar, Wade, Mansour, Fall, Nicolas, Benoit, Aminata, Nakoulima, Rémy, Amalvict, Yaya, Diémé, Bécaye, Fall, Boubacar, Wade, Bakary, Diatta, Bruno, Pradines |
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| Rok vydání: | 2016 |
| Předmět: |
Repetitive Sequences
Amino Acid Plasmodium falciparum Drug Resistance Protozoan Proteins Artesunate Gene Expression Antimalarials Inhibitory Concentration 50 Mechanisms of Resistance parasitic diseases Humans Protein Isoforms Malaria Falciparum Naphthyridines Fluorenes Lumefantrine Polymorphism Genetic Quinine Amodiaquine Chloroquine Artemisinins Senegal Mefloquine Ethanolamines Doxycycline Quinolines ATP-Binding Cassette Transporters Asparagine |
| Zdroj: | Antimicrobial agents and chemotherapy. 61(3) |
| ISSN: | 1098-6596 |
| Popis: | Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the Plasmodium falciparum multidrug resistance 6 gene (Pfmdr6) and the ex vivo susceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine. |
| Databáze: | OpenAIRE |
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