Molecular Evidence that the Vancouver Island Cryptococcus gattii Outbreak has Expanded into the United States Pacific Northwest

Autor: Byrnes, Edmond J., Bildfell, Robert, Frank, Sheryl A., Mitchell, Thomas G., Marr, Kieren, Heitman, Joseph
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Popis: Cryptococcus neoformans frequently causes fungal meningitis in immunocompromised patients, whereas the related species C. gattii is restricted to tropical and subtropical regions,where it usually infects immunocompetent individuals.An outbreak of C. gattii infection that began in 1999 on Vancouver Island has resulted in endemic C. gattii infection and caused numerous human and veterinary infections; the outbreak's range has spread to mainland British Columbia. The outbreak-related isolates have been molecular type VGIIa, the major genotype, or VGIIb, the minor genotype. Since 2006, human and veterinary cases of C. gattii infection have emerged in Washington and Oregon. Multilocus sequence typing demonstrates the spread of C. gattii VGIIa and VGIIb from Vancouver Island to the Pacific Northwest. Clinical strains recovered in Oregon represent a unique VGIIc genotype.
Databáze: OpenAIRE