| Autor: |
John, Steytler, Elna, van der Ryst, Charles, Craig, Ben, Van Baelen, Jeremy, Nuttall, Neliëtte, van Niekerk, John, Mellors, Urvi, Parikh, Carole, Wallis |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clin Infect Dis |
| ISSN: |
1537-6591 |
| Popis: |
BACKGROUND: Participants with human immunodeficiency virus (HIV) seroconversion in The Ring Study, a phase 3 trial of dapivirine vaginal ring (DVR), or in the open-label extension trial dapivirine ring extended access and monitoring (DREAM) were offered enrollment in an observational cohort study (IPM 007) to assess clinical presentation and response to antiretroviral therapy (ART). METHODS: Participants’ HIV infection was managed at local treatment clinics according to national treatment guidelines. IPM 007 study visits occurred 3 and 6 months after enrollment and every 6 months thereafter. Assessments included plasma HIV-1 RNA, CD4(+) T-cell counts, and recording of HIV/AIDS-associated events and antiretroviral use. Post hoc virology analyses were performed for participants identified with virologic failure. RESULTS: One hundred fifty-one of 179 eligible participants (84.4%) enrolled into IPM 007; 103 had previously received the DVR in the Ring or DREAM studies, and 48 had received placebo in The Ring Study. HIV-1 RNA and CD4(+) T-cell counts after 12 months’ follow-up were similar for participants who used the DVR in The Ring Study and DREAM, compared to those who received placebo. Of the 78 participants with a study visit approximately 6 months after ART initiation, 59 (75.6%) had HIV-1 RNA |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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