| Autor: |
N, Bouchet, J, Bischerour, S, Germon, J, Guillard, M, Dubernet, M C, Viaud-Massuard, O, Delelis, V, Ryabinin, Y, Bigot, C, Augé-Gouillou |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Mini reviews in medicinal chemistry. 9(4) |
| ISSN: |
1389-5575 |
| Popis: |
We described chemical inhibitors of Mos1 transposition. Some were already known to affect a related prokaryotic transposase (Tn5) or HIV-1 integrase, whereas the other were new compounds in this field. The new compounds were all organized around a bis-(heteroaryl)maleimides scaffold. Their mechanism of action depended on the chemical substitutions on the scaffold. The cross-activity, between HIV-1 integrase and Mos1 transposase, of the new group of inhibitors showed that Mos1 transposase could constitute an excellent surrogate HIV-1 inhibitor screen. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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