[The characteristics of homologous DNA recombination in somatic cells. III. Intrachromosomal recombinations of the aminoglycoside phosphoribosyltransferase gene in transgenic mice]

Autor: I N, Shvemberger, A N, Ermilov, L V, Smagina, L B, Ginkul, S R, Romanov, O K, Glebov
Rok vydání: 1996
Předmět:
Zdroj: Tsitologiia. 38(3)
ISSN: 0041-3771
Popis: Intrachromosomal homologous recombination has been revealed in the DNA from transgenic mice of three pedigrees. The recombination DNA of aminoglycosid phosphoribosiltransferase (neo) gene was observed in liver, kidney, spleen, heart, skeletal muscle, germinal glands and tail. It is concluded that the constructed model can be used for studying recombinations in cells of various organs and tissues both in the course of embryogenesis and during their malignant transformation and tumor progression.
Databáze: OpenAIRE