| Autor: |
D H, Verity, R W, Vaughan, E, Kondeatis, W, Madanat, H, Zureikat, F, Fayyad, J E, Marr, C A, Kanawati, G R, Wallace, M R, Stanford |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 27(2) |
| ISSN: |
0960-7420 |
| Popis: |
Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease. The expression of both soluble and tissue ICAM-1 is increased in Behçet's disease (BD) but the contribution of ICAM-1 gene polymorphisms to this disease remains unknown. Associations with BD have been reported for genes within the MHC, including HLA-B51, TNF and MICA, but the role of non-MHC genes in BD remains largely unexplored. We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). Among patients, no association was found between the presence of ocular disease and ICAM-1 polymorphisms. While the functional correlate of this polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain, which is independent of the MHC, may contribute to disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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