| Autor: |
I, Zanolla, E, Tiengo, F, Zanotti, M, Trentini, C, Mortellaro, A G, Lucchina, D, Licastro, S, Dal Monego, G, Soliani, B, Zavan |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
European review for medical and pharmacological sciences. 26 |
| ISSN: |
2284-0729 |
| Popis: |
A hernia of the abdominal wall is an opening of the muscles in the abdominal wall, which is frequently treated via the application of a surgical mesh. The purpose of this research is to study how human adipose-derived stem cells (hADSCs) interact with Phasix™ Mesh, a commercially available mesh for hernia repair. Studying how cells derived from the abdominal region behave with Phasix™ Mesh is crucial to improve the state of the art of current surgery and achieve effective tissue restoration.hADSCs were seeded onto Phasix™ Mesh, a fully resorbable surgical mesh of poly (4-hydroxybutyric acid) (P4HB). Cell viability was assessed through MTT assay, and cell growth and adhesion were evaluated via multiple imaging techniques and gene imaging profiling.Results confirm that the nets support cells proliferation, extracellular matrix production and increasing of angiogenetic factor.Butyric acid-based nets are promising scaffolds for abdominal wall reconstruction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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