| Autor: |
R J, Bochis, L E, Olen, F S, Waksmunski, H, Mrozik, P, Eskola, P, Kulsa, G, Wilks, J E, Taylor, J R, Egerton, D A, Ostlind, G, Olson |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Journal of medicinal chemistry. 24(12) |
| ISSN: |
0022-2623 |
| Popis: |
Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2-alpha]pyridine-2-carbamate to be the most potent derivative in the series. However, evaluation in sheep indicated that its anthelmintic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2-alpha]pyridine-2-carbamate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
