| Autor: |
S, Lee, N, Kollias, D J, McAuliffe, T J, Flotte, A G, Doukas |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Pharmaceutical research. 16(11) |
| ISSN: |
0724-8741 |
| Popis: |
Assess the feasibility of in vivo topical drug delivery in humans with a single photomechanical wave.Photomechanical waves were generated with a 23 nsec Q-switched ruby laser. In vivo fluorescence spectroscopy was used as an elegant non-invasive assay of transport of 5-aminolevulinic acid into the skin following the application of a single photomechanical wave.The barrier function of the human stratum corneum in vivo may be modulated by a single (110 nsec) photomechanical compression wave without adversely affecting the viability and structure of the epidermis and dermis. Furthermore, the stratum corneum barrier always recovers within minutes following a photomechanical wave. The application of the photomechanical wave did not cause any pain. The dose delivered across the stratum corneum depends on the peak pressure and has a threshold at approximately 350 bar. A 30% increase in peak pressure, produced a 680% increase in the amount delivered.Photomechanical waves may have important implications for transcutaneous drug delivery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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