Corticosteroid therapy for COVID-19
| Autor: | Pulakurthi, Yashwitha Sai, Pederson, John M., Saravu, Kavitha, Gupta, Nitin, Balasubramanian, Prasanth, Kamrowski, Shelby, Schmidt, Megan, Vegivinti, Charan Thej Reddy, Dibas, Mahmoud, Reierson, Natalie L., Pisipati, Sailaja, Joseph, Betsy Ann, Selvan, Pragadeesh Thamarai, Dmytriw, Adam A., Keesari, Praneeth Reddy, Sriram, Varsha, Chittajallu, Spandana, Brinjikji, Waleed, Katamreddy, Rewanth R., Chibbar, Richa, Davis, Amber R., Malpe, Manashree, Mishra, Hemant K., Kallmes, Kevin M., Hassan, Ameer E., Evanson, Kirk W. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
SARS-CoV-2
coronavirus COVID-19 adrenal cortex hormones severe acute respiratory syndrome coronavirus-2 Respiration Artificial respiratory distress syndrome COVID-19 Drug Treatment Treatment Outcome Odds Ratio Humans Systematic Review and Meta-Analysis Research Article Randomized Controlled Trials as Topic |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background: Corticosteroid treatment is an effective and common therapeutic strategy for various inflammatory lung pathologies and may be an effective treatment for coronavirus disease 2019 (COVID-19). The purpose of this systematic review and meta-analysis of current literature was to investigate the clinical outcomes associated with corticosteroid treatment of COVID-19. Methods: We systematically searched PubMed, medRxiv, Web of Science, and Scopus databases through March 10, 2021 to identify randomized controlled trials (RCTs) that evaluated the effects of corticosteroid therapies for COVID-19 treatment. Outcomes of interest were mortality, need for mechanical ventilation, serious adverse events (SAEs), and superinfection. Results: A total of 7737 patients from 8 RCTs were included in the quantitative meta-analysis, of which 2795 (36.1%) patients received corticosteroids plus standard of care (SOC) while 4942 (63.9%) patients received placebo and/or SOC alone. The odds of mortality were significantly lower in patients that received corticosteroids as compared to SOC (odds ratio [OR] = 0.85 [95% CI: 0.76; 0.95], P = .003). Corticosteroid treatment reduced the odds of a need for mechanical ventilation as compared to SOC (OR = 0.76 [95% CI: 0.59; 0.97], P = .030). There was no significant difference between the corticosteroid and SOC groups with regards to SAEs and superinfections. Conclusion: Corticosteroid treatment can reduce the odds for mortality and the need for mechanical ventilation in severe COVID-19 patients. |
| Databáze: | OpenAIRE |
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