| Autor: |
Terho, Lehtimäki, Petri, Ojala, Riikka, Rontu, Sirkka, Goebeler, Pekka J, Karhunen, Marja, Jylhä, Kari, Mattila, Saara, Metso, Hannu, Jokela, Matti, Nikkilä, Erkki, Wuolijoki, Antti, Hervonen, Mikko, Hurme |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Journal of the American Geriatrics Society. 53(9) |
| ISSN: |
0002-8614 |
| Popis: |
To establish whether the relationship between interleukin-6 (IL-6) and plasma lipid and C-reactive protein (CRP) concentrations is different in Finnish nonagenarians than in middle-aged subjects with lower inflammatory status.Cross-sectional.Observational cohort study concentrating on the oldest old.Nonagenarians (n=291, mean age+/-standard deviation 90+/-1; 68 men, 223 women) who lived in the Tampere municipality in southern Finland and a middle-aged control population from the same area (n=227, aged 44+/-8).Plasma high sensitive CRP and lipid concentrations were analyzed using an automatic analyzer and IL-6 levels using enzyme-linked immunosorbent assay.Plasma concentrations of IL-6 (4.39+/-5.25 vs 1.88+/-1.98 pg/mL) and CRP (3.54+/-4.98 vs 1.53+/-1.91 mg/L) were significantly higher in nonagenarians than in middle-aged subjects (P.001). In nonagenarians, plasma CRP levels increased (P.001) and plasma total cholesterol (P=.006), low-density lipoprotein cholesterol (P=.02), and high-density lipoprotein cholesterol (P=.002) levels decreased according to IL-6 quartiles. In middle-aged subjects, similar associations were not found.The relationship between IL-6 and plasma CRP and cholesterol levels in nonagenarians with enhanced systemic inflammation differs from that of middle-aged subjects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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