Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit

Autor:	I P, Ivanov, R F, Gesteland, J F, Atkins
Rok vydání:	2000
Předmět:	Base Sequence Molecular Sequence Data Frameshifting Ribosomal Regulatory Sequences Nucleic Acid Feedback Evolution Molecular Polyamines Animals Humans Nucleic Acid Conformation RNA Catalytic RNA Messenger Survey and Summary Codon Sequence Alignment Conserved Sequence Phylogeny
Zdroj:	Nucleic acids research. 28(17)
ISSN:	1362-4962
Popis:	The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e06a755e75c1d9b02348ff2a855dfa7a https://pubmed.ncbi.nlm.nih.gov/10954585 Zobrazit plný text záznamu