dextro-Naloxone or levo-naloxone reverses the attenuation of morphine antinociception induced by lipopolysaccharide in the mouse spinal cord via a non-opioid mechanism

Autor:	Hsiang-En, Wu, Han-Sen, Sun, Caleb W, Cheng, Maia, Terashvili, Leon F, Tseng
Rok vydání:	2006
Předmět:	Analgesics Opioid Lipopolysaccharides Male Mice Morphine Spinal Cord Naloxone Narcotic Antagonists Animals Pain Stereoisomerism Neuroglia Injections Spinal
Zdroj:	The European journal of neuroscience. 24(9)
ISSN:	0953-816X
Popis:	Glial stimulation by intrathecal injection of lipopolysaccharide (LPS) attenuated the tail-flick inhibition produced by morphine given intrathecally in the spinal cord of the male CD-1 mice. The phenomenon has been defined as antianalgesia. The effects of dextro-naloxone or levo-naloxone on the attenuation of morphine-produced tail-flick inhibition induced by LPS were then studied. Pretreatment with dextro-naloxone or levo-naloxone reversed the attenuation of the morphine-produced tail-flick inhibition induced by LPS. Pretreatment with dextro-naloxone or levo-naloxone alone did not affect the morphine-produced tail-flick inhibition. It is concluded that dextro-naloxone and levo-naloxone block the LPS-induced antianalgesia against morphine antinociception via a non-opioid mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e05f74104e80a334d7d08d72aef726c1 https://pubmed.ncbi.nlm.nih.gov/17100845 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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