| Autor: |
O A, Aksenov, E A, Murina, E M, Kogan, G A, Platonova, N S, Sidorova, A L, Timkovskiĭ |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Voprosy virusologii. 40(2) |
| ISSN: |
0507-4088 |
| Popis: |
Modification of poly(G).poly(C) with cys-diaminodichloroplatinum (cys-DDP) at the level of rb = 0.02 increased the in vivo antiviral and interferon-inducing activity of the complex, in contrast to the data reported for complex poly(G).poly(C). Antiinfluenza activity in this case depends on the method of modification and increases more intensively when a ready complex is treated with cys-DDP, as against treatment of poly(G) alone before the formation of a complex with poly(C). If rb is increased, the activity reduces again. Modification with trans-DDP at rb = 0.02 also leads to an increase of antiinfluenza activity of poly(G).poly(C), but mainly after pretreatment of poly(G). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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