Genomic Aberrations in Circulating Tumor DNAs from Palbociclib-Treated Metastatic Breast Cancer Patients Reveal a Novel Resistance Mechanism

Autor:	Maysa, Abu-Khalaf, Chun, Wang, Zhenchao, Zhang, Rui, Luo, Weelic, Chong, Daniel P, Silver, Frederick, Fellin, Rebecca, Jaslow, AnaMaria, Lopez, Terrence, Cescon, Wei, Jiang, Ronald, Myers, Qiang, Wei, Bingshan, Li, Massimo, Cristofanilli, Hushan, Yang
Rok vydání:	2022
Zdroj:	Cancers. 14(12)
ISSN:	2072-6694
Popis:	Previously undescribed molecular mechanisms of resistance will emerge with the increased use of cyclin-dependent kinase 4/6 inhibitors in clinical settings. To identify genomic aberrations in circulating tumor DNA associated with treatment resistance in palbociclib-treated metastatic breast cancer (MBC) patients, we collected 35 pre- and post-treatment blood samples from 16 patients with estrogen receptor-positive (ER
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dfea74ff7f57f445bb62dd5f1721918d https://pubmed.ncbi.nlm.nih.gov/35740538 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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