| Autor: |
J I, Maiztegui, K T, McKee, J G, Barrera Oro, L H, Harrison, P H, Gibbs, M R, Feuillade, D A, Enria, A M, Briggiler, S C, Levis, A M, Ambrosio, N A, Halsey, C J, Peters |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
The Journal of infectious diseases. 177(2) |
| ISSN: |
0022-1899 |
| Popis: |
Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
