Does Ca2+ release from the sarcoplasmic reticulum influence heart rate?

Autor:	Y K, Ju, D G, Allen
Rok vydání:	2001
Předmět:	Amphibians Sarcoplasmic Reticulum Epinephrine Biological Clocks Heart Rate Sodium Animals Calcium Sodium-Calcium Exchanger
Zdroj:	Clinical and experimental pharmacologyphysiology. 28(8)
ISSN:	0305-1870
Popis:	1. The present review summarizes the evidence that Ca2+ release from the sarcoplasmic reticulum (SR) is an important contributor to the systolic rise in [Ca2+]i (the Ca2+ transient) and influences the pacemaker firing rate. 2. We believe that the mechanism whereby [Ca2+]i influences firing rate is through the dependence of the Na+-Ca2+ exchanger on [Ca2+]i. 3. Extrusion of Ca2+ by the electrogenic Na+-Ca2+ exchanger produces an inward current that contributes to the pacemaker currents. Confocal images of Ca2+ indicate the distribution of [Ca2+]i and Ca2+ sparks add to the evidence that Ca2+ release from SR is involved in pacemaker activity. 4. The normal pathway for increased heart rate is sympathetic activation; we discuss the evidence that part of the chronotropic effect of beta-adrenoceptor stimulation is through the modulation of SR Ca2+ release. 5. These studies show that Ca2+ handling by the pacemaker cells makes an important contribution to the regulation of pacemaker activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dfc423ec9cccffc388fc6c689b4ef4d8 https://pubmed.ncbi.nlm.nih.gov/11473539 Zobrazit plný text záznamu Plný text