Megakaryocyte expansion and macrophage infiltration in bone marrow of rats subchronically treated with MNX, N-nitroso environmental degradation product of munitions compound RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine)

Autor:	Sindhura, Ramasahayam, Sridhar, Jaligama, Sahar M, Atwa, Joshua T, Salley, Marissa, Thongdy, Benny L, Blaylock, Sharon A, Meyer
Rok vydání:	2016
Předmět:	Dose-Response Relationship Drug Triazines Macrophages Organ Size Blood Cell Count Rats Sprague-Dawley Biodegradation Environmental Explosive Agents Bone Marrow Hematopoiesis Extramedullary Animals Environmental Pollutants Female Megakaryocytes Spleen
Zdroj:	Journal of applied toxicology : JAT. 37(8)
ISSN:	1099-1263
Popis:	Hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), environmental degradation product of munitions hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), causes seizures in rats with acute oral exposure like parent RDX. Our previous studies have additionally reported hematotoxicity with acute MNX exposure manifested as myelosuppression, anemia and splenic hemosiderosis. This study explored whether MNX administered subchronically continued to target bone marrow to elicit peripheral blood cytopenia. Female Sprague-Dawley rats were gavaged daily for 4 or 6 weeks with 47 mg kg
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dfc10a1ff73c6f20f5d97fc2e75acb08 https://pubmed.ncbi.nlm.nih.gov/28138994 Zobrazit plný text záznamu Plný text