| Autor: |
Zvi, Laron, Moshe, Iluz, Rivka, Kauli |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 22(2) |
| ISSN: |
1532-2238 |
| Popis: |
Head circumference (HC) is a simple and practical measure of brain size, development and longitudinal measurements of the HC in childhood are an index of brain growth.To determine the effects of long IGF-I deficiency and treatment on HC in patients with Laron syndrome (LS).20 untreated adult LS patients, aged 48.4±11.2 years and 13 LS patients treated between ages of 5.6±4 to 11.3±3 years were studied. 15 patients with congenital IGHD treated between age 6.1±4 and 13±4 by hGH served as controls.HC was expressed as standard deviation (SD) and Ht as SDS. HC was measured and plotted on Nellhaus charts. Linear height (Ht) was measured by a Harpenden Stadiometer.The mean HC deficit of the adult untreated LS males was -2.9±0.6 SD compared to a Ht deficit of -7.0±1.7 SDS. The HC of the LS adult females was -3.6±1 SD compared to a Ht SDS of -6.9±1.5 (p0.001). IGF-I treatment (150-200 μg/kg once daily) increased the HC from -3.3±0.9 (m±SD) to normal values (0.87±1.8 SD) (p0.001) in 11/13 children. The Ht SDS deficit decreased only by 1.5 SDS. hGH treatment of cIGHD children increased the HC from -2.0±1.8 to 0.3±1.2 SD and the Ht SDS from -4.8±1.6 to 1.6±1.0. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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