| Autor: |
I M, Vikhliantsev, Iu A, Alekseeva, M D, Shpagina, S N, Udal'tsov, Z A, Podlubnaia |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Biofizika. 47(4) |
| ISSN: |
0006-3029 |
| Popis: |
Changes in the molecular weight and functional properties of the C and X proteins from skeletal muscles and the C protein from the cardiac muscle of hibernating ground squirrels Citellus undulatus at different stages of the hibernation were studied. A decrease in the molecular weight of the C protein from fast fibers of skeletal muscles of hibernating ground squirrels compared with awakening and active animals was revealed. The appearance of shorter molecules of the C protein upon hibernation was accompanied by a lowering of its capacity to enhance the actin-activated ATPase activity of control myosin and by the inhibition of its Ca(2+)-sensitivity. No similar changes were observed for the skeletal X protein and the cardiac C protein. The influence of the skeletal C protein on the main functional properties of myosin allows one to draw a conclusion about its contribution to the inhibition of contractile activity of skeletal muscles upon hibernation. The physiological significance of the changes in the C protein upon hibernation is discussed in connection with similar changes in some cardiomyopathies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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