| Autor: |
I, Schauer, U J, Schauer, K, Thielmann |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology, therapy, and toxicology. 22(11) |
| ISSN: |
0174-4879 |
| Popis: |
In vitro effects of DL-propranolol (a therapeutically used beta-blocker with local anesthetic properties), L-propranolol (having both beta-blocking and unspecific local anesthetic properties), D-propranolol (having local anesthetic, but much less beta-blocking properties), and talinolol (a therapeutically used beta-1-blocker with much less local anesthetic properties) on lecithin: cholesterol acyl transferase (LCAT) activity in human plasma were compared. Both D-propranolol and L-propranolol inhibited LCAT activity, the former being a little more effective. The racemic mixture showed intermediate dose-effect curves. In no case could a complete inhibition be achieved. Talinolol exhibited no effect on LCAT activity. Therefore, the inhibition of LCAT activity by beta-blocking drugs may be connected with their local anesthetic properties. Because LCAT inhibition is followed by a decrease of HDL cholesterol and an increase of triglycerides in plasma, it is recommended to use only beta-blockers without such side effects on lipoprotein metabolism for therapeutical purposes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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