Caffeine-induced inversion of prostaglandin E

Autor:	Momoka, Yamaguchi, Naoki, Dohi, Akira, Ooka, Shin-Ya, Saito, Tomohisa, Ishikawa
Rok vydání:	2021
Předmět:	Inflammation Liver Cirrhosis Male Mice Time Factors Gene Expression Regulation Caffeine Cyclic AMP Hepatic Stellate Cells Animals Cells Cultured Dinoprostone
Zdroj:	Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 142
ISSN:	1950-6007
Popis:	Liver inflammation leads to the activation of hepatic stellate cells (HSCs), resulting in the development of liver fibrosis. The present study aimed to investigate the effects of prostaglandin EHSCs isolated from mice were activated by culturing in a medium supplemented with 10% fetal bovine serum for 7 days on plastic plates. The activation of HSCs was evaluated by immunofluorescence of α-smooth muscle actin in HSCs. Comprehensive gene expression analysis was performed using mRNA-sequencing to compare HSCs cultured for 1 or 7 days, with or without PGEPGEThe effect of PGE
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::df95a45cb914ea3bb248b248ada88dba https://pubmed.ncbi.nlm.nih.gov/34388524 Zobrazit plný text záznamu Full Text from ScienceDirect