Value of determination of beta 2-microglobulin in toxic nephropathy and interstitial nephritis

Autor:	L W, Statius van Eps, G H, Schardijn
Rok vydání:	1984
Předmět:	Male Cadmium Poisoning Pyelonephritis Gallium Radioisotopes Middle Aged Kidney Aminoglycosides Diabetes Mellitus Type 1 Urinary Tract Infections Humans Nephritis Interstitial Kidney Diseases Radionuclide Imaging beta 2-Microglobulin Diatrizoate Meglumine Glomerular Filtration Rate
Zdroj:	Wiener klinische Wochenschrift. 96(18)
ISSN:	0043-5325
Popis:	Beta 2-microglobulin (beta 2-m) is a low molecular weight protein of importance in the evaluation of the reabsorptive capacity of the proximal kidney tubule. This is based on the properties of beta 2-m: the daily production is constant and it leaves the body almost exclusively by glomerular filtration; 99.9% of the filtered amount is reabsorbed by the proximal tubule. The urinary excretion of beta 2-m is elevated (greater than 370 micrograms/day) in patients suffering from proximal tubular dysfunction with disturbance of tubular reabsorption. It is of great value as a marker of tubular involvement in toxic nephropathies, interstitial nephritis and the non-invasive method of choice to distinguish between renal and lower urinary tract infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::df8fecd708669c6e36321cfdce799167 https://pubmed.ncbi.nlm.nih.gov/6395507 Zobrazit plný text záznamu