| Autor: |
S Ia, Proskuriakov, N I, Riabchenko, L M, Iakushina, V P, Ivannik, R V, Sin'kova, V V, Konev, G A, Popov, V I, Riabchenko, I P, Grosheva |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Voprosy meditsinskoi khimii. 38(6) |
| ISSN: |
0042-8809 |
| Popis: |
Accumulation and excretion of beta-carotene in rat liver tissue were studied when the carotinoid was intraperitoneally administered as olive oil as suspension and a water liposomal suspension. Single injection of the liposomal form of beta-carotene caused an increase in its content in liver tissue. If beta-carotene was administered at a dose of 10 mg/kg its maximal content 44 mg/g of the tissue was observed within one day, and at a dose of 50 mg/kg, its maximal content constituted 178 mg/g within two days. Administration of beta-carotene as an oil suspension at a dose of 50 mg/kg led to a considerably slight accumulation in rat liver tissue with the maximal value of 12 mg/kg of the tissue within two days. Possible use of beta-carotene various forms, as well as experimental models for study their biological activity are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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