| Autor: |
E A, Nechaeva, T G, Riabicheva, N A, Varaksin, T Iu, Sen'kina, N V, Zhilina, M P, Smolina, B N, Zaĭtsev |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Vestnik Rossiiskoi akademii meditsinskikh nauk. (11) |
| ISSN: |
0869-6047 |
| Popis: |
Designing of non-injection methods of immunization against measles has recently turned into a topical issue. Development of mucosal vaccines ensuring the "entry gate" immunity, which is highly effective in airborne infection, is in the focus of attention. The authors developed a method of microencapsulating the viral particles into the matrix of pH-dependent polymers. Microencapsulated live measles vaccine shaped as 0.6-2.0 microm particles was obtained. The specific activity of measles virus in the drug was 3.36-4.31 log TCD50/0.5 ml. In subcutaneous immunization of guinea pigs with capsules, the best results were obtained in a single administration of vaccine based on ethylcrylate, sodium alginate/ chitosan and sodium slaginate/HMDA. In the intranasal administration of vaccine based on sodium alginate/spermin and sodium alginate/HMDA, there was a need in 2 and 3 stages of immunization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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