| Autor: |
Bülent, Aydinli, Mehmet Ilhan, Yildirgan, Gürkan, Oztürk, Sabri Selçuk, Atamanalap, Kamil Yalçin, Polat, Mahmut, Başoğlu, Cemal, Gündoğdu, Halis, Süleyman, Ahmet, Kiziltunç, Nesrin, Gürsan, Durkaya, Oren |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Ulusal travma ve acil cerrahi dergisi = Turkish journal of traumaemergency surgery : TJTES. 13(4) |
| ISSN: |
1306-696X |
| Popis: |
To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model.Gastric ulcers were induced by oral ingestion of indomethacin. Thirty rats were used in the study. The rats were divided into 3 groups, and given either SC (n=10) at a dose of 50 mg/kg or omeprazole (n=10), or no treatment (n=10, the control group). In addition to the measurements of ulceration areas, the sum of gastric tissue nitrite (NO2-) and nitrate (NO3-) were evaluated as an indicator of gastric tissue NO level. All the measurements were done at 6th hour of oral administration of indomethacin.The mean values of ulceration areas were 4.0+/-2.31, 3.0+/-2.00, and 21.4+/-8.43 in the SC, omeprazole and control groups, respectively. The mean values of ulceration areas in the SC-treated group was lower than that of the control group. The contents of NO were 32.2+/-3.05, 24.8+/-3.23 and 21.0+/-0.82 (micromol/g protein) in gastric tissue in indomethacin, SC, omeprazole and control groups, respectively, The content of NO in the SC-treated groups was significantly higher than control group (p0.001).Sildenafil citrate may have a role in protecting gastric mucosa from the damage caused by indomethacin. This effect may be associated with the increased level of NO in gastric tissue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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