| Autor: |
C A, McKenzie, J S, Sinsheimer, A A, Adeyemo, R D, Cox, L, Southam, A, Hugill, N, Bouzekri, M, Lathrop, T E, Forrester, R S, Cooper, R, Ward |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Annals of human genetics. 69(Pt 2) |
| ISSN: |
0003-4800 |
| Popis: |
Gamete competition models were used to explore the relationships between 13 ACE gene polymorphisms and plasma ACE concentration in a set of Nigerian families. Several markers in the 5' and 3' regions of the gene were significantly associated with ACE concentration (P10(-4)). Multi-locus genotypes comprising different combinations of markers from the 5' UTR and the 3' region of the gene were also analysed; in addition to G2350A, in the 3' region, two markers from the 5' UTR (A-5466C and A-240T) were found to be associated with ACE concentration. These results are consistent with reports that have suggested the presence of at least two ACE-linked QTLs, and demonstrate the utility of gamete competition models in the exploratory investigation of the relationship between a quantitative trait and multiple variants in a small genomic region. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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