| Autor: |
P, Polakis, M, Hart, B, Rubinfeld |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Advances in experimental medicine and biology. 470 |
| ISSN: |
0065-2598 |
| Popis: |
The molecular events that contribute to the progression of colon cancer are beginning to unravel. An initiating and probably obligatory event is the oncogenic activation of beta-catenin. This can come about by the loss of its negative regulator the adenomatous polyposis coli (APC) protein, or by mutations in the beta-catenin gene that result in a more stable protein product. The interaction between APC and beta-catenin, and additional proteins that affect assembly and signaling along this pathway, are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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