Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) and the AIDS Clinical Trials Group (ACTG)
| Autor: | W M, el-Sadr, D C, Perlman, J P, Matts, E T, Nelson, D L, Cohn, N, Salomon, M, Olibrice, F, Medard, K D, Chirgwin, D, Mildvan, B E, Jones, E E, Telzak, O, Klein, L, Heifets, R, Hafner |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Ofloxacin AIDS-Related Opportunistic Infections Antitubercular Agents Sputum Levofloxacin Microbial Sensitivity Tests Mycobacterium tuberculosis Pyrazinamide Drug Administration Schedule Treatment Outcome Recurrence Isoniazid Humans Drug Therapy Combination Female Rifampin Tuberculosis Pulmonary Ethambutol |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 26(5) |
| ISSN: | 1058-4838 |
| Popis: | This study examined whether adding levofloxacin to a standard four-drug regimen improved the 8-week culture response and compared effectiveness of 9 versus 6 months of intermittent therapy for human immunodeficiency virus-related pansusceptible pulmonary tuberculosis. Patients were randomized to receive either four or five drugs, the fifth being levofloxacin. Patients who completed induction therapy were randomized to complete 9 versus 6 months of intermittent therapy with isoniazid and rifampin. In the randomized induction phase, 97.3% of patients in the four-drug group and 95.8% in the five-drug group had sputum culture conversion at 8 weeks (P = 1.00). In the continuation phase, one patient (2%) assigned to 9 months and two patients (3.9%) assigned to 6 months of therapy had treatment failure/relapse (P = 1.00). In conclusion, this study showed that levofloxacin added no benefit to a highly effective, largely intermittent, four-drug induction regimen. Both 9 and 6 months of intermittent therapy were associated with low treatment failure/relapse rates. |
| Databáze: | OpenAIRE |
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