| Autor: |
Chuan, Xu, Annie, Wang, William, Honnen, Abraham, Pinter, Warren K, Weston, Jane A, Harness, Aarthi, Narayanan, Theresa L, Chang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
EC Microbiol |
| Popis: |
Brilacidin (PMX-30063), a non-peptide defensin-mimetic small molecule, inhibits SARS-CoV-2 viral infection but the anti-viral mechanism is not defined. Here we determined its effect on the specific step of the viral life cycle. Brilacidin blocked SARS-CoV-2 infection but had no effect after viral entry. Brilacidin inhibited pseudotyped SARS-CoV-2 viruses expressing spike proteins from the P.1 Brazil strain and the B.1.1.7 UK strain. Brilacidin affected viral attachment in hACE2-dependent and independent manners depending on the concentrations. The inhibitory effect on viral entry was not mediated through blocking the binding of either the spike receptor-binding domain or the spike S1 protein to hACE2 proteins. Taken together, brilacidin inhibits SARS-CoV-2 infection by blocking viral entry and is active against SARS-CoV-2 variants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
