Autor: |
Nicolas, Gourdin, Marion, Bossennec, Céline, Rodriguez, Selena, Vigano, Christelle, Machon, Camilla, Jandus, David, Bauché, Julien, Faget, Isabelle, Durand, Nicolas, Chopin, Olivier, Tredan, Julien C, Marie, Bertrand, Dubois, Jérôme, Guitton, Pedro, Romero, Christophe, Caux, Christine, Ménétrier-Caux |
Rok vydání: |
2017 |
Předmět: |
|
Zdroj: |
Cancer research. 78(13) |
ISSN: |
1538-7445 |
Popis: |
The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effector CD4 |
Databáze: |
OpenAIRE |
Externí odkaz: |
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