Autocrine Adenosine Regulates Tumor Polyfunctional CD73

Autor:	Nicolas, Gourdin, Marion, Bossennec, Céline, Rodriguez, Selena, Vigano, Christelle, Machon, Camilla, Jandus, David, Bauché, Julien, Faget, Isabelle, Durand, Nicolas, Chopin, Olivier, Tredan, Julien C, Marie, Bertrand, Dubois, Jérôme, Guitton, Pedro, Romero, Christophe, Caux, Christine, Ménétrier-Caux
Rok vydání:	2017
Předmět:	Ovarian Neoplasms Adenosine Apyrase Interleukin-17 Breast Neoplasms T-Lymphocytes Helper-Inducer GPI-Linked Proteins T-Lymphocytes Regulatory Antineoplastic Agents Immunological Lymphocytes Tumor-Infiltrating Costimulatory and Inhibitory T-Cell Receptors Drug Resistance Neoplasm Humans Female Tumor Escape 5'-Nucleotidase
Zdroj:	Cancer research. 78(13)
ISSN:	1538-7445
Popis:	The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effector CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dee14d03c2a564df23177cfa310cf2d3 https://pubmed.ncbi.nlm.nih.gov/29559470 Zobrazit plný text záznamu