Synthetic resin acid derivatives selectively open the hK

Autor:	Nina E, Ottosson, Malin, Silverå Ejneby, Xiongyu, Wu, Argel, Estrada-Mondragón, Michelle, Nilsson, Urban, Karlsson, Melanie, Schupp, Salomé, Rognant, Thomas Andrew, Jepps, Peter, Konradsson, Fredrik, Elinder
Rok vydání:	2021
Předmět:	Epilepsy Patch-Clamp Techniques Phenylenediamines KCNQ3 Potassium Channel Substrate Specificity Resins Synthetic Xenopus laevis Seizures Larva Oocytes Animals Humans KCNQ2 Potassium Channel Anticonvulsants Carbamates Ion Channel Gating Zebrafish
Zdroj:	EpilepsiaREFERENCES. 62(7)
ISSN:	1528-1167
Popis:	About one third of all patients with epilepsy have pharmacoresistant seizures. Thus there is a need for better pharmacological treatments. The human voltage-gated potassium (hKIon channels were expressed in Xenopus oocytes or mammalian cell lines and explored with two-electrode voltage-clamp or automated patch-clamp techniques. Unwanted vascular side effects were investigated with isometric tension recordings. Antiseizure activity was studied in an electrophysiological zebrafish-larvae model.Fourteen resin acid derivatives were tested on hKThe described resin acid derivatives hold promise for new antiseizure medications, with reduced risk for adverse effects compared with retigabine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dea4348710abf810491400b825565ccf https://pubmed.ncbi.nlm.nih.gov/34085706 Zobrazit plný text záznamu Plný text